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Phospholipase D PLD is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The inhibitor enhanced apoptosis in colorectal cancer CRC cells but not in normal colonic cells, and in vitro cardiotoxicity was not observed. In cancer, therapeutic engagement of immunogenic cell death ICD leads to more effective responses by eliciting the antitumor immunity of T cells. PLD1 inhibition subsequently enhanced the phagocytosis of cancer cells by macrophages through the surface expression of costimulatory molecules; as a result, the cancer cells were more susceptible to cytotoxic T-cell-mediated killing.

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Lau 4,5,6,7 , Kenneth K. Leung 4 , Adrienne Y. Chan 4,5,6,10 , Celine S. Chui 6,11,12 , Ian C. Wong 4,5,6,7,13 , Ju-Young Shin 1,2, Background Polypharmacy among older people represents a global challenge due to its association with adverse drug events. The reported prevalence of polypharmacy varies widely across countries, and is particularly high in Asian countries. However, there is no multinational study using standardised measurements exploring variations in prescribing trends. Design Multinational, retrospective, time-trend, observational study using a common study protocol. We estimated the annual prevalence of polypharmacy and calculated average annual percentage change AAPC to assess the time trends. Results A total of 1. The highest prevalence of polypharmacy was observed in Hong Kong Conclusions Polypharmacy prevalence in older people was higher in Hong Kong, Taiwan and South Korea, with an increasing trend over time, compared with Australia and the United Kingdom. Our findings underline the necessity to monitor polypharmacy among older people in Asia by conducting government-level interventions and introducing medicine-optimisation strategies. Setting Outpatient and community settings.

The highest prevalence of polypharmacy was 이혜성 in Hong Kong Thursday 16 November

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Lee was in a relationship with Jun Hyun-moo , a former announcer turned broadcast personality and host. This biographical article about a South Korean personality is a stub. You can help Wikipedia by expanding it. This Asian biographical article related to television is a stub. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools.

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Friday 10 November Friday 3 November Friday 29 December Wednesday 10 January Sunday 1 October Tuesday 27 February Friday 23 February Saturday 18 November We estimated the annual prevalence of polypharmacy and calculated average annual percentage change AAPC to assess the time trends. Go directly to shout page.

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Thursday 2 November Thursday 8 February Thursday 19 October Thursday 7 December However, the contribution of PLD inhibition to the antitumor response remains unknown. Saturday 30 September Sunday 25 February Wednesday 13 March Sunday 12 November Thursday 4 January Wednesday 1 November Friday 24 November Tuesday 16 January Tuesday 19 September