Alpha inhibin

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Federal government websites often end in. The site is secure. As a result of its expression in corresponding normal cell types, inhibin alpha INHA is used as an immunohistochemical marker for adrenocortical neoplasms and testicular or ovarian sex cord stromal tumors. However, other tumors can also express INHA. To comprehensively determine INHA expression in cancer, a tissue microarray containing 15, samples from different tumor types and subtypes was analyzed by immunohistochemistry.

Alpha inhibin

Inhibin is a peptide hormone that is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH. The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of the testis and various cells of the fetoplacental unit. Inhibin may be used as a differential marker for adrenocortical tumors, placenta and gestational trophoblastic lesions and sex cord stromal tumors. Normal testis or normal ovary, adrenal gland. Groome, N G et al Monoclonal and polyclonal antibodies reactive with the amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 9 1 : 2. Groome, N G et al Preparation of monoclonal antibodies to beta A subunit of ovarian inhibin using a synthetic peptide immunogen. Hybridoma 10 2 : 3. Journal of Pathology 4. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms.

Till S. Cluggage M.

Click here to buy online! Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits A or B , while their alpha subunits are identical.

Federal government websites often end in. The site is secure. As a result of its expression in corresponding normal cell types, inhibin alpha INHA is used as an immunohistochemical marker for adrenocortical neoplasms and testicular or ovarian sex cord stromal tumors. However, other tumors can also express INHA. To comprehensively determine INHA expression in cancer, a tissue microarray containing 15, samples from different tumor types and subtypes was analyzed by immunohistochemistry.

Alpha inhibin

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. This article on a gene on human chromosome 2 is a stub.

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Introduction The inhibin alpha subunit protein INHA is a member of the TGF-beta transforming growth factor-beta superfamily encoded by a gene located at 2q35 [ 1 , 2 , 3 ]. IVD - CE. Kononen J. Singh P. Sample pathology report. An experienced pathologist performed manual analysis of the stained TMA slides. All work was carried out in compliance with the Helsinki Declaration. Selected - PA This is all the more pressing since other tumor entities have also been reported to express inhibin alpha across many tumor types, although the reported positivity rates are highly variable. Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. Using MSVAR, significant cytoplasmic staining is seen in adrenocortical cells A , Sertoli and Leydig cells of the testis B , the corpus luteum C and theca cells D of the ovary, decidua cells in the pregnant uterus E , and in trophoblast cells of the first trimester placenta F. Survival curves were calculated according to Kaplan—Meier. Ovarian thecoma. Inhibin is a useful marker to differentiate GCT from other epithelial neoplasms with similar histology; inhibin staining in other epithelial neoplasms is usually weak or negative and limited to nontumoral stromal theca cells Rom J Morphol Embryol ; Cancer Res.

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A Iczkowski K. Due to the rareness of immunohistochemically detectable INHA expression in most cancer types, we were only able to compare INHA immunostaining data with available clinical data in neuroendocrine tumors, clear cell renal cell carcinoma, and colorectal adenocarcinoma. Uhlen M. Clone: AMY IVD - CE. Human testis: immunohistochemical staining for inhibin alpha showing cytoplasmic staining of Sertoli cells. Inhibin alpha is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7. The panels show an INHA immunostaining of variable intensity in Sertoli and Leydig cells of the testis A , corpus luteum of the ovary B , cortical cells of the adrenal gland C , cytotrophoblast cells of the first trimester placenta D , and of the mature placenta E , chorion cells of the placenta F , decidua cells in placenta adjacent tissue G , and granulosa cells of follicular cysts of the ovary H. Hybridoma 10 2 : 3. Order code MP. You may place your order and it will be fulfilled when the product is back in stock. Answers B, C and D are incorrect because inhibin staining is most often negative in soft tissue neoplasms like liposarcomas, schwannomas and neurofibromas and may only be useful as part of an antibody panel in very limited cases. Harshbarger J. All authors agree to be accountable for the content of the work.