Dehp full form

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Federal government websites often end in. The site is secure. Diethylhexyl phthalate DEHP is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo. Diethylhexyl phthalate DEHP is the most common member of the class of phthalates, which are used as plasticizers in polymer products to make plastic flexible.

Dehp full form

DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan circa and in the United States in DEHP has two stereocenters, [8] located at the carbon atoms carrying the ethyl groups. As a result, it has three distinct stereoisomers, [8] consisting of an R , R form, an S , S form diastereomers , and a meso R , S form. As most 2-ethylhexanol is produced as a racemic mixture, commercially-produced DEHP is therefore almost always racemic as well, and consists of equal amounts of all three stereoisomers. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide. Manufacturers of flexible PVC articles can choose among several alternative plasticizers offering similar technical properties as DEHP. DEHP is a component of many household items, including tablecloths, floor tiles, shower curtains, garden hoses, rainwear, dolls, toys, shoes, medical tubing, furniture upholstery, and swimming pool liners.

DEHP does not usually evaporate into the air or easily dissolve in water. N verify what is Y N? Swan S.

Di 2-ethylhexyl phthalate DEHP is a man-made chemical. It is a colorless liquid with a slight odor. DEHP is found throughout the environment at low levels. It gets into the environment mostly through the disposal of plastic waste in landfills. Most DEHP in the environment is found in sediments and soil. It sticks strongly to soil and breaks down slowly when it is near the surface.

Context - Diethylhexyl-phthalate DEHP is a substance that is mainly used as an additive in plastics to make them more flexible. Phthalates are widely used as additives in a wide range of plastics and other materials that are found in many consumer products. They make plastics, such as PVC, soft and flexible. As they are not chemically bound to plastics, they can be released from consumer products. There is public concern about phthalates because of their widespread use and occurrence in the environment as well as their potential effects on human health. There is a wide range of different phthalates , each having specific properties, uses, and health effects. In , an estimated one to four million tonnes of DEHP were produced in the world. DEHP is not chemically bound to the polymer products that it is added to.

Dehp full form

Chemical Classification: Phthalates. Summary: Di 2-ethylhexyl phthlate DEHP is a manufactured chemical that is commonly added to plastics to make them flexible. DEHP is a colorless liquid with almost no odor. DEHP is present in plastic products such as wall coverings, tablecloths, floor tiles, furniture upholstery, shower curtains, garden hoses, swimming pool liners, rainwear, baby pants, dolls, some toys, shoes, automobile upholstery and tops, packaging film and sheets, sheathing for wire and cable, medical tubing, and blood storage bags. ToxFAQs - Fact sheet that answers the most frequently asked questions about a contaminant and its health effects.

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Mitchell F. Wipe up dust regularly, using a damp cloth. The selenium Se status plays a crucial role in protecting the liver structure and function because it is a redox regulator. Refractive index n D. The authors analyzed the concentration of DEHP and other common chemicals such as PCBs in testes from dogs from five different world regions. Although more research is needed to develop alternatives to DEHP that gives the same benefits of being soft and flexible, which are required for most medical procedures, if a procedure requires one of these devices and if patient is at high risk to suffer from DEHP then a DEHP alternative should be considered if medically safe. Journal of Toxicological Sciences. DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Koch H. Biology of Reproduction.

The toxicity to exposure ratio for different human populations and scenarios has been used to derive the MOS. For the scenarios on production and industrial use, monitored data for inhalation exposure and modelled values for dermal exposure have been used as a realistic worst case. For the scenario industrial end-use of products containing DEHP, it is assumed that relatively high work temperatures, aerosol generation and considerable skin contact occur.

MEHP is suspected to have an obesogenic effect. Klaunig J. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo. In conclusion, the evidence linking personal care products to endocrine-disruptive effects in humans is lacking for the most part. As a library, NLM provides access to scientific literature. Archived from the original on Christopher After weeks of DEHP exposure, kidney weights were significantly lower than those of the controls [ 62 ]. In vitro and rodent studies indicate that DEHP is involved in many molecular events, including increased cell proliferation, decreased apoptosis , oxidative damage , and selective clonal expansion of the initiated cells; all of which take place in multiple sites of the human body. Interactive image.