Dr raul p de guzman

Brill Nijhoff. Brill Wageningen Academic.

The ultimate goal is to develop novel therapeutics strategies for patients with this rare disease. We aim to understand the role of endosomal ion transport for neuronal function, with focus on two endo-lysosomal transporters, ClC-3 and ClC-4, that regulate the pH and [Cl-] in multiple endosomal compartments. A group of neurodevelopmental disorders, in which slight changes in ClC-3 or ClC-4 transport functions cause epilepsy and intellectual disability as well as anxiety, depression, hyperactivity, and bipolar disorders, illustrate the importance of these transporters for higher brain functions. We use transgene technology genetically modified mouse models and shRNA lentiviral transduction , patch-clamp electrophysiology, membrane cell capacitance measurements, carbon fiber amperometry, photolytic uncaging of intracellular calcium, molecular biology, and confocal microscopy to understand the cellular and molecular function of ClC-3 and ClC-4 in neuronal health and disease and to identify potential strategies for the treatment of CLCN3- and CLCN4-related disorders. Comini, M. A, Franzen, A. Sierra-Marquez, J.

Dr raul p de guzman

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Dr raul p de guzman

Zeus A. Ledivina V. Books and Monographs. Guzman, Raul P. Patterns in Decision-Making.

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De Guzman Raul P. DOI: Middle East and Islamic Studies. Author Newsletter. Corporate Social Responsiblity. Add to Cart. Literature and Cultural Studies. Data Sharing Policy. He, H. The molecular and phenotypic spectrum of CLCN4-related epilepsy. Comini, M. Guzman, R. Offices Worldwide. Ordering from Brill. Sierra-Marquez, J.

After completing his residency in general surgery, he undertook research training in the Cardiology Branch of the National Heart, Lung and Blood Institute at the National Institutes of Health in Bethesda, MD and subsequently completed a fellowship in vascular surgery at Stanford University Hospital. His clinical interests relate to patients with diabetic vascular disease and ischemic foot ulcers. His research focuses on the role of arterial calcification in lower extremity ischemia.

Forschungsthemen We aim to understand the role of endosomal ion transport for neuronal function, with focus on two endo-lysosomal transporters, ClC-3 and ClC-4, that regulate the pH and [Cl-] in multiple endosomal compartments. IHRS Biosoft. Author Newsletter. He, H. View Expanded. Open Access Content. Sign in to annotate. Literature and Cultural Studies. Brill mentis. A, Franzen, A. Abstract Metadata. Open Access.