Imidazopyridine

Imidazopyridine scaffold has gained tremendous importance over the past few imidazopyridine. Imidazopyridines have been expeditiously used for the rationale design and development of novel synthetic analogs for various therapeutic disorders, imidazopyridine.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. Derivatives 6d , 6e and 6f bearing methyl, tertiary butyl and dichloro-phenyl moieties on the triazole ring, respectively, were the compounds with the highest potential.

Imidazopyridine

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Yi, Y.

A CuI-catalyzed aerobic oxidative synthesis of imidazo[1,2- a ]pyridines from 2-aminopyridines and acetophenones is compatible with a broad range of functional groups. The reaction also enables the formation of alkenyl-substituted imidazoheterocycles by using unsaturated ketones as substrates. Preliminary mechanistic studies indicate that this reaction proceeds through a catalytic Ortoleva-King reaction. Zhang, Z. Chen, W. Wu, Y.

Federal government websites often end in. The site is secure. Box , United Arab Emirates. Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry.

Imidazopyridine

Imidazopyridine scaffold has gained tremendous importance over the past few decades. Imidazopyridines have been expeditiously used for the rationale design and development of novel synthetic analogs for various therapeutic disorders. A wide variety of imidazopyridine derivatives have been developed as potential anti-cancer, anti-diabetic, anti-tubercular, anti-microbial, anti-viral, anti-inflammatory, central nervous system CNS agents besides other chemotherapeutic agents.

Sons rio cibolo

Again in , Kuthyala et al. The equilibrium time ranges of 44, 15 and 55 ns were observed for complexes of 6d , 6e and 6f with c-Met, respectively. A study by Masters et al. Figure 1. Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met. Agarose 1. Zhang, W. Institutional Review Board Statement Not applicable. Synthesis of this moiety from the easily available chemicals is desirable due to its tremendous use in the various branches of chemistry. Indeed, we assumed that the nitrogen atoms in 1,2,3-triazole and oxygen atom in the linker might serve as potential hydrogen bond acceptor moieties.

Federal government websites often end in. The site is secure. Imidazopyridines constitute one of the most important scaffolds in medicinal chemistry, as their skeleton could be found in a myriad of biologically active molecules.

Agarose 1. New Lab Start-Up. The calculated RMSD values for the re-docking process of the native inhibitors were 0. Firuzi, O. The completion of reactions and purity of the products were checked by TLC on the glass-backed silica gel sheets Silica Gel 60 GF and spots visualized under UV light nm. An ultrasound-promoted three-component reaction provides C3-cyanomethylated imidazo[1,2- a ]pyridines under catalyst-free, oxidant-free, and mild conditions. Background samples contained all reagents except for the enzyme. Accessed 15 Jan Signal Transduct. Chioua M. Tools Tools.