Macquarie university dementia research centre

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver, macquarie university dementia research centre. Hence, there is an unmet need for new therapeutic avenues in dementia. The multidisciplinary team of the Dementia Research Centre works closely with medicinal chemists and international pharmaceutical industry to accelerate translation into novel therapies for these devastating diseases.

Please also feel free to contact us if you are not eligible for any of the studies below, or if you have any suggestions or questions. We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you. You will also do some cognitive tests, answer questionnaires, provide a blood sample and have some body measurements taken. You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. If you would like to volunteer, please contact the team at: E: adnet. Previous work by Professor Ralph Martins and his team has found that the effects of testosterone therapy may extend to both the accumulation and clearance of amyloid beta from the brain and may potentially prevent the disease.

Macquarie university dementia research centre

The DRC currently includes eight research groups. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. These include small molecules, antibodies and gene therapy approaches. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans. Operating our own AAV core allows immediate access to this cutting-edge technology for all our research teams, accelerating multiple discovery research projects and our gene-therapy pipeline. Brain neurons remain one of the hardest cell types to culture, due to their inability to multiply and fastidious culturing conditions. Techniques to grow neurons in single layers have long been developed but remain both labour and costs-intensive. At the same time these 2D cultures do not resemble the complexity of the brain. To overcome these limitations, the Dementia Research Centre has brought together experts in cellular neurobiology and peptide hydrogel chemistry and developed new 3D neuronal culture systems, based on our proprietary matrix technology. Learn more about 3D hydrogel culture technologies. The Dementia Research Centre is home to one of the largest colonies of genetically modified mouse models of dementia in Australia. These models have assisted us in unravelling novel disease mechanisms.

We examine clinically and pathologically well-characterised human brain tissue from sporadic and genetic neurodegenerative disorders sourced from national and international Brain Banks and Research Institutions, and transgenic models of dementia.

Lars graduated from the University of Ulm in Germany and completed his thesis at the University … View full profile. Yuanyuan completed a PhD in Biomedical Science in Currently a Postdoctoral Fellow at Macquarie University in the Dementia Research Centre, focusing on the pathogenesis of Alzheimer's disease and related gene-target therapy. Previously working as a researcher and lecturer at the Key Laboratory … View full profile. Seonghee worked as a postdoctoral fellow at DGIST where her work focused on investigating the pathogenic mechanism… View full profile.

Our vision is a world without MND. Our mission is to provide world-class care for people living with MND and to develop new effective treatments for this devastating disease. Our MND clinicians work collaboratively under a robust multidisciplinary team MDT model, which is a well-established, evidence-based treatment approach. The MDT approach means that patients are often seen by several expert clinicians in the same room at the same time. During consultation, patients receive a detailed assessment. Our team will discuss the options and agree on a comprehensive diagnosis and treatment plan in partnership with you. The team also collaborates with other medical professionals from MQ Health as required, including psychologists, physicians, pain specialists, physiotherapists and rehabilitation specialists.

Macquarie university dementia research centre

View more. The researcher will also integrate into ongoing research projects focusing on understanding disease mechanisms in dementia. The role will involve administering and testing novel gene therapies in a range of mouse models for various neurological disorders including epilepsy and dementia , as well as further developing and testing novel gene therapies in various cell culture systems.

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We would like to thank all of our participants of this study for your time and dedication to our research, and hope to publish our results soon! You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. Hence, there is an unmet need for new therapeutic avenues in dementia. Tietz group team members. Coconut oil in Alzheimer's Disease prevention — pilot study COAD-P Phase 1 clinical trial to investigate the effects of coconut oil specifically medium-chain triglycerides on ketone body production and cognitive function for the prevention of Alzheimer's disease in healthy older adults. Skip to content Skip to navigation. This is first done by a phone questionnaire, followed by two clinic visits to discuss the trial and your medical history with a study doctor, blood tests, and memory assessments. Van Eersel group team members. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans. Activities Activities per year 1 Membership of an association.

Organisational unit : University. Faculty of Medicine, Health and Human Sciences.

Participation requires initial screening to identify volunteers who are safe and suitable to take part. Search this site. Emily is currently a PhD candidate with the Dementia Research Centre focusing on inhibitory interneurons in Alzheimer's disease. Brain neurons remain one of the hardest cell types to culture, due to their inability to multiply and fastidious culturing conditions. Ittner group team members. Skip to content Skip to navigation. Liming Hou completed her Ph. A competitive advantage of the Dementia Research Centre is the direct access to new disease models through its direct operation of the Genome Editing Macquarie service. Currently a Postdoctoral Fellow at Macquarie University in the Dementia Research Centre, focusing on the pathogenesis of Alzheimer's disease and related gene-target therapy. These models need to accurately recapitulate aspects of the human conditions and at the same time be assessible for experimental manipulation. Our research.