Ondansetron moa

Ondansetronsold under the brand name Zofran among others, is a medication used to prevent nausea and ondansetron moa caused by cancer chemotherapyradiation therapyor surgery.

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Ondansetron moa

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Alexandria Griddine ; Jeffrey S. Authors Alexandria Griddine 1 ; Jeffrey S. Bush 2. Ondansetron is one of the medications most commonly used for the empiric treatment of nausea and vomiting. Ondansetron has excellent utility as an antiemetic drug, and it is effective against nausea and vomiting of various etiologies. Common uses of ondansetron include the prevention of chemotherapy-induced and radiation-induced nausea and vomiting, the prevention of postoperative nausea and vomiting, and off-label use for the prevention of nausea and vomiting associated with pregnancy. However, it is not effective for motion sickness-induced nausea.

Researchers examined 84 trials, with 11, people receiving ondansetron, published between and September Toggle limited content width. Agonists: ondansetron moa Aminorex Amphetamines e.

Ondansetron is a highly potent and selective antagonist at 5-HT3 receptors. Its anti-emetic actions were first revealed by its ability to antagonize retching and vomiting induced by chemotherapy and radiotherapy in animals and man. Subsequently, the availability of labelled 5-HT3 receptor ligands allowed identification of 5-HT3 receptors, located at highest densities in the area postrema, nucleus tractus solitarius NTS , in other areas of the brain, and on afferent terminals of the vagus nerve. Postoperative nausea and vomiting may be caused by various factors: the anaesthetic, associated drugs, the surgical procedure, movement of the patient, sex, weight and pain. These factors mediate their effects via the higher brain circuits, the vestibular nuclei, the chemoreceptor trigger zone in the area postrema, or the upper gastrointestinal tract via the vagus nerve, influencing motor and visceral emetic outputs in the hind-brain. The absence of other pharmacological effects of ondansetron ensures an absence of side-effects.

Ondansetron , sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy , radiation therapy , or surgery. Common side effects include diarrhea , constipation , headache , sleepiness , and itchiness. Ondansetron was patented in and approved for medical use in Ondansetron is indicated for the prevention of chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting. Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy. It is typically used after other antinausea drugs have failed. A large multi-center cohort study found no association between ondansetron exposure and fetal risk compared to other antiemetic drugs. Ondansetron is one of several antiemetic drugs used during the vomiting phase of cyclic vomiting syndrome. Trials in emergency department settings support the use of ondansetron to reduce vomiting associated with gastroenteritis and dehydration. Its use reduced hospital admissions, but was also associated with higher rates of return visits to the emergency department.

Ondansetron moa

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Metabolism: The liver is the primary site of metabolism. The tablet will dissolve in a few seconds and can be swallowed with saliva. Expert Opin Drug Metab Toxicol. Off-label use for the prevention of nausea and vomiting associated with pregnancy. Gastrointestinal Ondansetron. If you are taking the rapidly disintegrating tablet, remove the tablet from the package just before you take your dose. NCBI Bookshelf. Ondansetron in pregnancy and risk of adverse fetal outcomes. Central effects are mediated by the antagonism of 5HT-3 serotonin receptors in the area postrema. Ondansetron , sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy , radiation therapy , or surgery.

Nausea and vomiting are common complaints seen by emergency department physicians and primary care clinicians daily. Other antiemetics that appear on this list with ondansetron include dexamethasone and metoclopramide. In the last year of its patent , the brand-name version of ondansetron was the 20th highest-selling brand-name drug in the United States, and its popularity continues today.

It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Christopher v. Turn recording back on. Adverse effects. Archived from the original on 14 December Delayed diagnosis of anaphylaxis secondary to ondansetron: A case report. Ask your doctor or pharmacist for more information. Other antiemetics that appear on this list with ondansetron include dexamethasone and metoclopramide. Topics Topics. Archived from the original on 12 January Oncologist consultation is necessary for CINV. StatPearls [Internet]. Concurrent administration of pimozide with ondansetron should be avoided due to the risk of QTc prolongation. Wikimedia Commons. Do not take more or less of it or take it more often than prescribed by your doctor.