Propolis side effects diarrhea

Propolis is a mixture of pollen and beeswax collected by bees from certain plants and trees. Rich in flavonoidsa class of antioxidants, propolis has a long history of use as a natural treatment for many health problems, propolis side effects diarrhea, but more research is needed in humans to support its use. Although found in small quantities in honey, propolis is also widely available in supplement form. For example, propolis is used as an ingredient in certain products applied directly to the skin, such as ointments and creams.

Federal government websites often end in. The site is secure. There are a number of disorders that affect the gastrointestinal tract. Such disorders have become a global emerging disease with a high incidence and prevalence rates worldwide. Inflammatory and ulcerative processes of the stomach or intestines, such as gastritis, ulcers, colitis, and mucositis, afflict a significant proportion of people throughout the world. The role of herbal-derived medicines has been extensively explored in order to develop new effective and safe strategies to improve the available gastrointestinal therapies that are currently used in the clinical practice.

Propolis side effects diarrhea

Federal government websites often end in. The site is secure. Brazilian green propolis is reported to have wide range of biological properties including antibacterial, anti-inflammatory, anti-influenza, and antioxidant activities. In the digestive system, a protective effect of propolis on gastric ulcer has been reported, but a laxative effect has not yet been reported. We investigated the effect and the mechanism of action of water and ethanol extracts of Brazilian green propolis. We also investigated the effects of WEP on gastrointestinal transit and contractional tension of the ileum to uncover the mechanism of action of WEP. WEP treatment significantly restored stool frequency and stool weight in clonidine-induced constipation model mice, but not in loperamide-induced constipation model mice. WEP treatment did not affect gastro-intestinal transit, but significantly increased the contractional tension of the isolated ileum of guinea pigs. These findings indicate that WEP has laxative effects both in normal mice and in clonidine-induced constipation model mice. The laxative effects of WEP might be mediated by increased contractional tension of the ileum exerted at least in part via activation of an acetylcholine receptor. Propolis is a hard solid substance that honeybees make by mixing botanical materials or resins to protect their hive from adverse environmental factors such as bacteria, mites, rain, etc. The chemical constituents of propolis vary according to the production region, and four types of propolis are recognized worldwide: European, Brazilian, Cuban, and Taiwanese [ 1 ]. Brazilian propolis is further classified into 12 types [ 2 ].

How to Store. Pereira E. Despite this wide range of its composition, the records indicate that propolis has been used in the folk medicine since BC [ 5 ].

Metrics details. Brazilian green propolis is reported to have wide range of biological properties including antibacterial, anti-inflammatory, anti-influenza, and antioxidant activities. In the digestive system, a protective effect of propolis on gastric ulcer has been reported, but a laxative effect has not yet been reported. We investigated the effect and the mechanism of action of water and ethanol extracts of Brazilian green propolis. We also investigated the effects of WEP on gastrointestinal transit and contractional tension of the ileum to uncover the mechanism of action of WEP. WEP treatment significantly restored stool frequency and stool weight in clonidine-induced constipation model mice, but not in loperamide-induced constipation model mice.

Propolis is a mixture of pollen and beeswax collected by bees from certain plants and trees. Rich in flavonoids , a class of antioxidants, propolis has a long history of use as a natural treatment for many health problems, but more research is needed in humans to support its use. Although found in small quantities in honey, propolis is also widely available in supplement form. For example, propolis is used as an ingredient in certain products applied directly to the skin, such as ointments and creams. In addition, propolis is sometimes found in nasal sprays and throat sprays, as well as in mouthwash and toothpaste. This article discusses the potential uses of propolis.

Propolis side effects diarrhea

Federal government websites often end in. The site is secure. There are a number of disorders that affect the gastrointestinal tract. Such disorders have become a global emerging disease with a high incidence and prevalence rates worldwide. Inflammatory and ulcerative processes of the stomach or intestines, such as gastritis, ulcers, colitis, and mucositis, afflict a significant proportion of people throughout the world. The role of herbal-derived medicines has been extensively explored in order to develop new effective and safe strategies to improve the available gastrointestinal therapies that are currently used in the clinical practice. Studies on the efficacy of propolis a unique resinous aromatic substance produced by honeybees from different types of species of plants are promising and propolis has been effective in the treatment of several pathological conditions. This review, therefore, summarizes and critiques the contents of some relevant published scientific papers including those related to clinical trials in order to demonstrate the therapeutic value of propolis and its active compounds in the treatment and prevention of gastrointestinal diseases.

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Therefore, the geographical location, plant sources, collection season, bee species, and solvents used in the extraction have an influence on the chemical composition and on the pharmacological activity of propolis preparation. Similar to the other flavonoids ingredients, quercetin exhibits anticancerous properties through stimulation of apoptotic pathways. Archive of Oncology. The Journal of Biological Chemistry. The difference between Figure 3 A and 3 B may attribute to difference of sensitivity between jejunum and ileum. Do not use propolis if you are allergic to bee products including honey. Huang S. Nair H. Gifu, Japan. From this point of view, WEP may induce the intestinal contraction via mechanism of direct stimulation of muscarinic receptor, endogenous acetylcholine release, or parasympathetic nerve stimulation, which is not mediated by serotonin. Traditional and herbal medicines are widely used for constipation, and many of these are classified into stimulant types, such as senna Senna alexandrina , aloe Aloe barbadensis miller , or castor oil Ricinus communis. British Journal of Nutrition. The apoptotic effect of CAPE is also associated with a selective scavenging ability for hydrogen peroxide as shown in human leukemic HL cell line study [ 99 ].

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Khan M. Biol Pharm Bull. There are various noxious agents to the stomach resulting in mucosal ulceration, such as Helicobacter pylori infections, prolonged ingestion of nonsteroidal anti-inflammatory drugs NAIDs , alcoholic drinks, psychological stress, and cigarette smoking. Barros M. Ghassemi L. Does the gastroprotective action of a medicinal plant ensure healing effects? Published online Mar It would have been prudent to utilize indistinguishable placebo as compared to the experimental treatment. We also investigated the effects of WEP on gastrointestinal transit and contractional tension of the ileum to uncover the mechanism of action of WEP. Fitzpatrick L. Assessment of the mutagenic activity of extracts of Brazilian propolis in topical pharmaceutical formulations on mammalian cells in vitro and in vivo. Join the Bee Buzz Community.