Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B[3] [4] dihydrotanshinonemiltirone[5] tanshinone Iand tanshinone IIA. The 30 cm 0. Salvia miltiorrhiza grow in whorls, with light purple to lavender blue corollas that are approximately 2, salvia miltiorrhiza.

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S.

Salvia miltiorrhiza

Chinese Medicine volume 5 , Article number: 22 Cite this article. Metrics details. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects. Danshen , the dried root of Salvia miltiorrhiza , is used in Chinese medicine to treat vascular disease. According to Chinese medicine theory, Danshen promotes blood flow and resolves blood stasis. Cerebral infarction is an ischemic condition of the brain including thrombosis, embolism or systemic hemodynamic hypotension. Cerebral infarction is often caused by atherosclerosis of large and small arteries.

Improvement in endothelial damage, atherosclerotic area in the abdominal aorta, and cholesterol deposition in the thoracic aorta. ECG improved.

Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy. Published by Elsevier B.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Salvia miltiorrhiza is one of the most widely used traditional medicines. The first gene is involved in the biosynthesis of bioactive tanshinones, the next two are involved in anthocyanin biosynthesis, whereas the last is involved in phenylpropanoid biosynthesis. The results suggest that S. They potentially play significant regulatory roles in the biosynthesis of bioactive compounds. Natural antisense transcripts NATs are a class of long noncoding RNAs, which transcribe in the opposite direction of protein-coding genes 1. Relatively, the transcripts of protein-coding genes were called sense transcripts STs.

Salvia miltiorrhiza

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Salvia miltiorrhiza Burge Danshen is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries.

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View author publications. Chinese J Clin Healthcare. Steroid Biochem. China J Chinese Med. Cardiovascular effects of Danshen. Pushpakumar S. The preclinical pharmacological effects of S. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects Additional file 1. Effects of S. Download as PDF Printable version. Coronary heart disease angina pectoris 35 14 days. Ineffective: No change in clinical symptoms.

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B , [3] [4] dihydrotanshinone , miltirone , [5] tanshinone I , and tanshinone IIA.

Interestingly, although salvianolate treatment did cause a decrease in the levels of total cholesterol and LDL, it had no effect on that of triglyceride and HDL. Voulgari C. Prescription Name. Tanshinone IIA reduces blood pressure in the 2K1C renovascular hypertension model of hamsters [ 26 ]. DOC Additional file 1: Possible pharmacological actions of Danshen for prevention and treatment of cerebral infarction. According to the Chinese pharmacopoeia [ 2 ], S. And the adverse effects completely alleviated after cessation of treatment. First, S. Journal of Natural Products. Huang L. Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging. Increased peripheral resistance, high cardiac output, an elevated heart rate, a reduction in the number or density of capillaries, increased active arteriolar vasoconstriction and decreased peripheral venous compliance account for the high pressure.