Spermine

Only showing spermine first 10 proteins. There are 26 proteins in total. Quantitative metabolomics services for biomarker discovery and validation, spermine.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Human spermine oxidase hSMOX plays a central role in polyamine catabolism.

Spermine

Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH. Spermine is associated with nucleic acids and is thought to stabilize helical structure, particularly in viruses. It functions as an intracellular free radical scavenger to protect DNA from free radical attack. Antonie van Leeuwenhoek first described crystals of spermine phosphate in human semen in A derivative of spermine, N 1 , N 12 -bis ethyl spermine also known as BESm was investigated in the late s along with similar polyamine analogues for its potential as a cancer therapy. Spermine biosynthesis in animals starts with decarboxylation of ornithine by the enzyme Ornithine decarboxylase in the presence of PLP. This decarboxylation gives putrescine.

These data suggest that the effect of SMS deletion with spermidine accumulation on CRC cell spermine is regulated by other biological processes. Clinical importance of eflornithine alpha-difluoromethylornithine for the treatment of malignant gliomas, spermine.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer CRC , but the underlying mechanism is incompletely characterized.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Putrescine, spermine, and spermidine are the important polyamines PAs , found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses. PAs are the integrated part of the cellular and genetic metabolism and help in transcription, translation, signaling, and post-translational modifications. At the cellular level, PA concentration may influence the condition of various diseases in the body. For instance, a high PA level is detrimental to patients suffering from aging, cognitive impairment, and cancer.

Spermine

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October

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References Casero, R. J Invest Dermatol. Peer reviewer reports are available. The indicated p -values were determined by two-tailed unpaired t test. Only showing the first 10 proteins. Kitazume, N. Together, these studies indicate an important interplay between polyamine synthesis and oncogenic signaling. Lymphoproliferative disease and autoimmunity in mice with increased miR expression in lymphocytes. Epub Sep Inhibition of murine N 1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL

Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells.

Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. This could make spermine a potential biomarker for the consumption of these foods. Spectroscopic and calorimetric characterization of spermine oxidase and its association forms. Levels of polyamines were normalized to protein amount. Discovery of metal-binding proteins by thermal proteome profiling Article 26 February Your source for quantitative metabolomics technologies and bioinformatics. Infobox references. In other projects. Delmore, J. DB Y. Polyamines in mammalian ageing: an oncological problem, too? Organic compounds. Submitted 02 Jun Polyamine biosynthesis is frequently dysregulated in human cancers, and in particular, is associated with early-stage CRC development