Stilbene

Federal government websites often end in. The site is secure. BoxKuopio, Finland. Numerous studies have highlighted the key roles stilbene oxidative stress and inflammation in aging-related diseases such as obesity, type 2 diabetes, stilbene, age-related macular degeneration AMDand Alzheimer's disease AD.

Classified as a diarylethene , it features a central ethylene moiety with one phenyl group substituent on each end of the carbon—carbon double bond. It has an E stereochemistry, meaning that the phenyl groups are located on opposite sides of the double bond, the opposite of its geometric isomer , cis -stilbene. Trans -stilbene occurs as a white crystalline solid at room temperature and is highly soluble in organic solvents. It can be converted to cis -stilbene photochemically , and further reacted to produce phenanthrene. Stilbene was discovered in by the French chemist Auguste Laurent. Stilbene exists as two possible stereoisomers.

Stilbene

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Structural characterization of bisretinoid A2E stilbene products and implications for age-related macular degeneration.

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Federal government websites often end in. The site is secure. Stilbene and its derivatives belong to the group of biologically active compounds. Some derivatives occur naturally in various plant species, while others are obtained by synthesis. Resveratrol is one of the best-known stilbene derivatives. Many stilbene derivatives exhibit antimicrobial, antifungal or anticancer properties. A thorough understanding of the properties of this group of biologically active compounds, and the development of their analytics from various matrices, will allow for a wider range of applications. This information is particularly important in the era of increasing incidence of various diseases hitherto unknown, including COVID, which is still present in our population. The purpose of this study was to summarize information on the qualitative and quantitative analysis of stilbene derivatives, their biological activity, potential applications as preservatives, antiseptics and disinfectants, and stability analysis in various matrices.

Stilbene

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Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells. Conclusions There is emerging in vitro and preclinical data to indicate that stilbene compounds are capable of suppressing oxidative stress, inflammation, and energy expenditure as well as modulating the secretion of neurotropic factors. Furthermore, a group of miRs microRNA expression involved in the regulation of the inflammatory response, that is, miR, miRb, miR, miRc2, miR, and miRa, were found to be highly correlated and altered in the group consuming the GE-RES for 12 months. For instance, Nrf2 has been shown to bind aryl hydrocarbon receptor AhR promoter, and vice versa, AhR element is found from Nrf2 promoter [ 69 ]. Karjalainen 2. HSL is active against diglycerines while ATGL selectively act on the first step in the triglycerine hydrolysis resulting in the formation of diglycerines and free fatty acids [ ]. Acetylation-deacetylation of the transcription factor Nrf2 nuclear factor erythroid 2-related factor 2 regulates its transcriptional activity and nucleocytoplasmic localization. Park S. Moore J. In particular, the induction of phase II enzymes via the Nrf2 pathway seems to play a key role in this defence system. Cullinan S. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Lipolysis regulates the key metabolic roles in the formation of adipose tissue size, weight, and obesity and two enzymes, adipose triglyceride lipase ATGL and hormone-sensitive lipase HSL , are involved in the lipolytic activity. Alzheimer's and Dementia.

Stilbenes are naturally occurring compounds with valuable properties such as antioxidant, anticancer, anti-diabetic, and anti-hypercholesterolemia activities. However, stilbene derivatives such as arylbenzofurans, bibenzyls, as well as stilbene oligomers also occur. Both aglycones and glycosylated forms can be found in plants, fruits, and vegetables.

Hsieh T. It has also been postulated that biotransformation, for example, dimerization, of stilbene compounds may be a way to enhance their efficacies as antihyperglycemic agents [ ]. Campbell M. Oxidative Medicine and Cellular Longevity. Thus this human trial provided the first indication that long-term supplementation with a GE-RES could downregulate the expression of key proinflammatory cytokines suggesting that this polyphenol treatment may have a true beneficial immunomodulatory impact in humans suffering from hypertension [ ]. In particular, the induction of phase II enzymes via the Nrf2 pathway seems to play a key role in this defence system. Interestingly, it was claimed by the authors that these daily doses of 0. Figure 1. Drugs are widely used to maintain the normal blood glucose level to prevent the development of hyperglycemia which may lead to a number of diabetic complications. Sachdeva M. Resveratrol [ 27 ]. Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents. Epidemiological studies have indicated that greater intakes of fruit and vegetable juices [ ] as well as higher intakes of blueberries or its component anthocyanidins [ 3 ] were associated with slower rates of cognitive decline. Trends in Biochemical Sciences. ISBN