White tablet 377

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If you are a consumer or patient please visit this version. Dosage and Administration 2. Warnings and Precautions 5. Tramadol hydrochloride tablets are an opioid agonist indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate 1. Limitations of Use 1. Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options [e.

White tablet 377

Tramadol is a prescription medication used to treat moderate to moderately severe pain in adults. Tramadol belongs to a group of drugs called opioid analgesics, which work by blocking pain signals in the body. This medication comes in immediate release tablet and that can be taken up to 6 times a day, with or without food. Tramadol also comes in extended-release tablet and capsule forms and are taken once a day, with or without food. Do not chew, divide, or break tramadol extended-release forms. Swallow them whole. Common side effects of tramadol include nausea, constipation, dry mouth, and fatigue. Tramadol can also cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how tramadol affects you. CYP2D6 is a protein in your body that is involved in the elimination of tramadol and other drugs from your body. Some patients have more or less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2D6 can vary greatly between individuals, and those having less of this protein are known as "poor metabolizers.

You should not take tramadol if you are allergic to it, or if you have:. Tramadol M1 c c c c 4, white tablet 377. Tramadol hydrochloride tablets may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.

The pill is an elliptical or oval-shaped, white-colored tablet with an imprint of "". It has been identified to contain tramadol hydrochloride in the strength of 50 mg. This tablet is manufactured by Sun Pharmaceutical Industries Ltd. The size of this tablet is 13 mm. It is only available as a prescription from the doctor. This medicine is known to belong to the narcotic analgesic drug class. Tamadol Price varies according to pharmacy and country.

If you are a consumer or patient please visit this version. Dosage and Administration 2. Warnings and Precautions 5. Tramadol hydrochloride tablets are an opioid agonist indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate 1. Limitations of Use 1. Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options [e. Life-Threatening Respiratory Depression. Serious, life-threatening, or fatal respiratory depression may occur with use of tramadol hydrochloride tablets, especially during initiation or following a dosage increase.

White tablet 377

Mary's Medical Park Pharmacy. Tramadol hydrochloride tablet, USP is a centrally acting analgesic. Its structural formula is:. The molecular weight of tramadol hydrochloride, USP is Tramadol hydrochloride, USP is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9. In addition, each tablet contains the following inactive ingredients: pregelatinized starch, lactose anhydrous, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, titanium dioxide, hypromellose and polysorbate Tramadol hydrochloride is a centrally acting synthetic opioid analgesic. Tramadol-induced analgesia is only partially antagonized by the opiate antagonist naloxone in several animal tests. Tramadol has been shown to inhibit reuptake of norepinephrine and serotonin in vitro , as have some other opioid analgesics.

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If a CYP3A4 inducer is discontinued, consider tramadol hydrochloride tablets dose reduction and evaluate patients at frequent intervals for signs of respiratory depression and sedation. After stopping a CYP3A4 inducer, as the effects of the inducer decline, the tramadol plasma concentration will increase [see Clinical Pharmacology Neonatal Opioid Withdrawal Syndrome NOWS If opioid use is required for an extended period of time in a pregnant woman, advise the patient of the risk of NOWS, which may be life-threatening if not recognized and treated. Skin: Rash. Available in:. Tramadol hydrochloride tablets should not be used for an extended period of time unless the pain remains severe enough to require an opioid analgesic and for which alternative treatment options continue to be inadequate. Uses of Tramadol Back to Top. The analgesic activity of tramadol hydrochloride tablets is due to both parent drug and the M1 metabolite [see Clinical Pharmacology Pinpoint pupils are a sign of opioid overdose but are not pathognomonic e. In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support if needed , is in place prior to initiating an opioid analgesic taper [ see Dosage and Administration 2. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. However, it is still unclear whether the effects of opioids on fertility is permanent or temporary. It also has weak antidepressant effects.

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Regularly evaluate patients, particularly when initiating and titrating tramadol hydrochloride tablets and when tramadol hydrochloride tablets are given concomitantly with other drugs that depress respiration [see Warnings and Precautions 5. Infertility Inform patients that use of opioids for an extended period of time may cause reduced fertility. Follow the directions on your prescription label carefully. Intervention: Avoid concomitant use. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of tramadol hydrochloride tablets and carbamazepine is not recommended. Follow patients receiving tramadol hydrochloride tablets and any CYP2D6 inhibitor for the risk of serious adverse events including seizures and serotonin syndrome, signs and symptoms that may reflect opioid toxicity, and opioid withdrawal when tramadol hydrochloride tablets are used in conjunction with inhibitors of CYP2D6 [see Drug Interactions 7 ]. Advise women that breastfeeding is not recommended during treatment with tramadol hydrochloride tablets [see Warnings and Precautions 5. Caution is advised when tramadol hydrochloride tablet is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as SSRIs, MAOIs, triptans, linezolid an antibiotic which is a reversible non-selective MAOI , lithium, or St. Labor or Delivery Opioids cross the placenta and may produce respiratory depression and psycho-physiologic effects in neonates. Avoid the use of tramadol hydrochloride tablets in patients with circulatory shock. Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models.