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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Euronetwork To analyze various types of PNS, euronetwork, frequent tumor and antibody associations, clinical characteristics of individual syndromes, euronetwork, and possible euronetwork and prognostic strategies. Design: Prospective case series and database study.

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date.

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Limbic encephalitis was associated with other syndromes in 49 patients, euronetwork. Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous euronetwork. Paraneoplastic neurologic syndrome PNS can affect any part of the nervous system, euronetwork.

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Euronetwork

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival.

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Cookies on Companies House services We use some essential cookies to make our services work. The preferred treatment in the cohort was intravenous immunoglobulin, 19 , 20 probably because of easy availability. Arch Neurol. I accept cookies. Although PNS is believed to affect several systems and to cause multifocal disorders, a single PNS was identified in patients Obtained funding : Giometto, Vitaliani, and Honnorat. Treatment of paraneoplastic neurological syndromes with antineuronal antibodies anti-Hu, anti-Yo with a combination of immunoglobulins, cyclophosphamide, and methylprednisolone. Besides confirming the clinical profile of many classical PNS in a much more extensive case series, analysis of database entries produced a number of interesting findings on the different clinical evolution of paraneoplastic cerebellar syndromes according to the onconeural antibody present, on the heterogeneity and prognosis of dysautonomic disorders, and on the clinical variability of paraneoplastic limbic encephalitis, as well. Select your language. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Analysis and interpretation of data : Giometto, Grisold, Honnorat, and Bertolini. The present study confirms that PNS influences oncologic patient survival. While the database was not designed for the conduction of epidemiological studies, the data is considered to represent the relative prevalence of each syndrome. Confirmation statement Next statement date 14 December due by 28 December Last statement dated 14 December The structure of the database was maintained throughout the study, and no modifications were permitted.

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Fact Sheet Results in Brief Reporting. Although the database was not designed for epidemiologic studies, we believe that our data represent the prevalence of each syndrome. Outcome status was available in patients The methods used by each center were reported in the database. A total of patients with SN were initially seen with subacute onset While the database was not designed for the conduction of epidemiological studies, the data is considered to represent the relative prevalence of each syndrome. Paraproteinemic neuropathies and myasthenia with thymoma were excluded. Surface antibodies such as VGKC were identified in few patients and were searched for only in the latter part of the study after their description in the literature. Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies. Free access to newly published articles. Between January 1, , and December 31, , the partnership collected information on patients, resulting in the largest database on PNS to date. The relative distribution of disorders confirms cerebellar degeneration and SN as the most frequently appearing types of PNS. Booklet My Booklet. Limbic encephalitis was associated with other syndromes in 49 patients. Limbic encephalitis constituted another major entity, followed by paraneoplastic encephalomyelitis and brainstem encephalitis.