Norleucine

Quantitative metabolomics services for biomarker discovery and validation.

A systematic name for this compound is 2-aminohexanoic acid. It is a white, water-soluble solid. Together with norvaline , norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar. Its biosynthesis has been examined. The incorporation of Nle into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase.

Norleucine

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List of abiotic amino acids. Quantitative metabolomics services for biomarker discovery norleucine validation.

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Federal government websites often end in. The site is secure. The broadly active glutamine antagonist 6-diazooxo-L-norleucine DON has been studied for sixty years as a potential anticancer therapeutic. Clinical studies of DON in the s using low daily doses suggested antitumor activity, but later phase I and II trials of DON given intermittently at high doses were hampered by dose-limiting nausea and vomiting. Further clinical development of DON was abandoned. Recently the recognition that multiple tumor types are glutamine dependent has renewed interest in metabolic inhibitors such as DON. Here we describe the prior experience with DON in humans.

Norleucine

A systematic name for this compound is 2-aminohexanoic acid. It is a white, water-soluble solid. Together with norvaline , norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar. Its biosynthesis has been examined. The incorporation of Nle into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. In Miller—Urey experiments probing prebiotic synthesis of amino acids, norleucine and especially norvaline are formed. It is nearly isosteric with methionine , even though it does not contain sulfur. Contents move to sidebar hide. Article Talk. Read Edit View history.

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Medium-chain fatty acids Amino fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds. Together with norvaline , norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar. Download as PDF Printable version. L-Norleucine exists in all eukaryotes, ranging from yeast to humans. Lanthionine Norleucine Diaminopimelic acid. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. In other projects. Carboxylic acids and derivatives. Interactive image. Solubility in water. Carboxyglutamic acid. Amino acids, peptides, and analogues.

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EC Number. Y verify what is Y N? Non-proteinogenic amino acids. Related compounds. Belongs to the class of organic compounds known as l-alpha-amino acids. You are using an unsupported browser. Cancer Metab. In Miller—Urey experiments probing prebiotic synthesis of amino acids, norleucine and especially norvaline are formed. Its biosynthesis has been examined. Interactive image. Auflage, Georg Thieme Verlag, Stuttgart The incorporation of Nle into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. Download Close. Categories : Alpha-Amino acids Non-proteinogenic amino acids. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.