Porhin

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Porhin

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Porins are beta barrel proteins that cross a cellular membrane and act as a pore, through which molecules can diffuse. They are present in the outer membrane of gram-negative bacteria and some gram-positive mycobacteria mycolic acid-containing actinomycetes , the outer membrane of mitochondria , and the outer chloroplast membrane outer plastid membrane. This means that the nonpolar residues face outward so as to interact with the nonpolar lipids of outer membrane , whereas the polar residues face inwards into the center of the beta barrel to create the aqueous channel. The specific amino acids in the channel determine the specificity of the porin to different molecules. The individual strands are joined together by loops and turns.

Porhin

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Gram-negative bacteria and their complex cell envelope, which comprises an outer membrane and an inner membrane, are an important and attractive system for studying the translocation of small molecules across biological membranes.

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