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During renal ischemia, ATP is degraded to hypoxanthine. When xanthine oxidase converts hypoxanthine to xanthine in the presence of molecular oxygen, superoxide radical O-2 is generated. We studied the role of O-2 and its reduction product OH X in mediating renal injury after ischemia. Male Sprague-Dawley rats underwent right nephrectomy followed by 60 min of occlusion of the left renal artery. The O-2 scavenger superoxide dismutase SOD was given 8 min before clamping and before release of the renal artery clamp. Plasma creatinine was lower in SOD treated rats: 1. Renal blood flow, measured after ischemia plus 15 min of reflow, was also greater in SOD treated than in control rats.

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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. It plays some critical roles in viral infection in pregnancy, such as its effects on the infection and replication of human cytomegalovirus in syncytiotrophoblasts. Interestingly, its role in the enhancement of Zika virus ZIKV infection and replication in first-trimester trophoblasts has recently been reported. The above up-to-date findings have opened one of the promising approaches to studying the mechanisms of viral infection during pregnancy with links to corresponding congenital syndromes. Our discussion focuses on viral infection during pregnancy, especially in the first trimester. In addition, we discuss promising approaches to performing further studies on this topic. The human body has to experience significant life changes, including pregnancy status for women.

Evidence of perinatal transmission of zika virus, french polynesia, december and february Analysis on the outcomes of hepatitis b virus perinatal vertical transmission: Nested case-control study.

Journal of Biological Regulators and Homeostatic Agents, 37 1 , , Doi: Frontiers Media SA Doi: Wiley, 49 5 , , Elsevier BV , Informa UK Limited Doi:

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Takada K. Interactions between human immunodeficiency virus type 1 and human cytomegalovirus in human term syncytiotrophoblast cells coinfected with both viruses. Pld;j 10m uaul o1ur? Thi at. IWmrrda , '. Frontiers Media SA Doi: NikLIc:r sen. Acl hir'-iW l gfWDl '! Licini C. C1 ClIli! Jji lillme ya-,mll. M c;il. Telephone 62

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Nie Y. Ii 't. O1lilllJjoihiJcild6 Mtie. Monsivais D. Fixed Appointment Number 06 Conflicts of Interest The authors declare no conflict of interest. Permissive cytomegalovirus infection of primary villous term and first trimester trophoblasts. No vaccine for preventing ZIKV infection is available, and its development is still in progress [ , , , ]. Trophoblasts and the Placenta Villi in Pregnancy During pregnancy, the placenta is not only a fetal organ responsible for nutrient and gas exchange between the mother and the fetus but also a barrier to protecting the fetus against various infectious pathogens, including viruses. These above findings suggest that a placental barrier is present, although limited, to prevent the fetus from intrauterine infection.